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What more can you do for overactive bladder?

If you’re still having to make frequent and urgent trips to the bathroom day and night, despite medication, you may be wondering what more you can do for your overactive bladder. You could think about our new research study.

The LO-BOT Study

This study is investigating an approved medication for overactive bladder
and urinary incontinence, called onabotulinumtoxinA (BOTOX®). Previous
studies have shown that this medication can improve the symptoms of
overactive bladder.


The aim of our study is to see if giving this medication in a different way will improve control over the frequency and urgency symptoms experienced by people with an overactive bladder and urinary incontinence.


The study duration is at least 25 weeks and up to 53 weeks, depending on how many times you receive the investigational medication. During this time, you will have 7–12 scheduled clinic visits and some phone contact from the study staff.


Could you qualify?

You may be able to take part in the study if you:

  • are 18 years of age, or older
  • have had overactive bladder symptoms for 6 months or more
  • have been taking an anticholinergic medication (e.g. Ditropan XL®, Detrol®, Enablex®) for at least 4 weeks, but it is not controlling your overactive
    bladder symptoms
  • have not had previous botulinum toxin therapy for any urological condition

If you qualify and choose to participate you will receive study-related care at no cost, as well as monitoring by a physician with experience in overactive bladder and urge incontinence. 



Why should you participate?

It is only through research studies like this that new medications can be developed, and your participation may help to advance medical knowledge and improve care for the millions of Americans coping with the symptoms of overactive bladder and urinary incontinence.


Meet the Provider

Janet Harris-Hicks, M.D.

Janet Harris-Hicks, M.D. FACOG,FPMRS 

Dr. Harris-Hicks focuses on providing care and treatments for urinary and fecal incontinence, pelvic-organ prolapse, overactive bladder, painful bladder syndrome and chronic pelvic pain.  She is also part of the Clinical Trials team at FirstHealth of the Carolinas.

She is board certified in Female Pelvic Medicine and Reconstructive Surgery and OB/GYN. She is also a member of American Urogynecology Society, Society for Urodynamics and Female Urology, International Urogynecological Association, American College of OB/GYN, American Medical Association and the North Carolina Medical Society.


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