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Colorectal Cancer

Protocol Number: NRG GI004

Protocol Title: Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy with or without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients with Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal Cancer

Eligibility: Men or women, ages 18 and older, diagnosed with Deficient DNA Mismatch repair metastatic colorectal cancer

Contact Information: (910) 715-2200


Protocol Number: Alliance A021703

Protocol Title: Randomized double-blinded phase III trial of high-dose vs. standard dose of vitamin D3 in patients with previously untreated metastatic colorectal cancer.

Eligibility:  Men and women, ages 18 and older with locally advanced/metastatic colorectal adenocarcinomas that have had no prior treatment for metastatic disease.

Contact Information: (910) 715-2200


Protocol Number: 16-002 / NSABP C-14

Protocol Title: CORRECT-MRD II: Second colorectal cancer clinical validation study to predict recurrence using a circulating tumor DNA assay to detect minimal residual disease

Eligibility:  Men and women age 18 and older, with stage II or III colorectal cancer, within 3 months of complete surgical resection of primary tumor.

Contact Information: (910) 715-2200


Protocol Number: Gritstone GO-010

Protocol Title: A Phase 2/3, Randomized, Open-Label Study of Maintenance GRT-C901/GRT-R902, A Neoantigen Vaccine, in Combination with Immune Checkpoint Blockade for Patients with Metastatic Colorectal Cancer

Eligibility:  Men and women age 18 and older with unresectable, metastatic histologically documented colorectal cancer.

Contact Information: (910) 715-2200


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