PRE-DETERMINE: Biologic Markers and MRI SCD Cohort Study
Coronary Artery Disease
Dr. Patrick Simpson
Men and women, ages 18 and older, with a history of coronary artery disease and documentation of either a prior myocardial infarction (MI) or mild to moderate left ventricular dysfunction (LVEF 35-50%). For additional criteria, call the Research Coordinator at Pinehurst Medical Clinic or visit the study weblink.
Brigham and Women's Hospital
This is a prospective, multi-center cohort study of patients with a history of coronary artery disease (CAD) and documentation of either a prior myocardial infarction (MI) or mild to moderate left ventricular dysfunction (LVEF 35-50%). The primary objective of this study is to identify a series of markers that alone or in combination specifically predict risk of arrhythmic death as compared to other causes of mortality among this at risk population of coronary heart disease (CHD) patients with preserved left ventricular ejection fraction (LVEF> 35%). In addition, we will also address whether these promising genetic markers and biomarkers advance sudden cardiac death (SCD) risk prediction when combined with advanced substrate imaging by participants that have undergone a CE-MRI at baseline.